Biopsy gives only a snapshot of tumour diversity

2 berichten / 0 nieuw
Offline
Berichten: 4226
Biopsy gives only a snapshot of tumour diversity

http://www.nature.com/news/biopsy-gives-only-a-snapshot-of-tumour-diversity-1.9998

A tumour can be a hotbed of diversity, British scientists have discovered. Just as different types of tumours have distinct genetic mutations, so do separate parts of the same tumour. .....

A clinician's conclusion about prognosis or the best course of treatment can be contradictory depending on which part of the tumour the biopsy is taken from. .....

As part of a clinical trial, Swanton’s team did a detailed analysis of the tumours of four patients with kidney cancer. They collected samples from several parts of the main tumours at various times during the trial, as well as from the organs to which the cancer had spread. .....

The main tumour was surprisingly varied. Just one-third of the mutations were common to all 14 samples, and one-quarter were found in just one sample and no others. ..... Swanton and his team even found signs of convergent evolution: the tumours had disabled the same gene — SETD2 — in three different ways.

Onderzoek is gepubliceerd in New England Journal of Medicine: http://www.nejm.org/doi/pdf/10.1056/NEJMoa1113205

Offline
Berichten: 1768

Ja, ik las dit net vanochtend in De Volkskrant (van gisteren). Helaas is dat artikel online alleen voor abonnees te lezen na een inlogcode. Vrij spectaculair nieuws vind ik.